Brain bioenergetics and redox state measured by ³¹P magnetic resonance spectroscopy in unaffected siblings of patients with psychotic disorders.

ABSTRACT:

Background

Brain bioenergetic anomalies and redox dysregulation have been implicated in the pathophysiology of psychotic disorders. The present study examined brain energy-related metabolites and the balance between nicotinamide adenine dinucleotide metabolites (oxidized NAD+ and reduced NADH) using ³¹P-magnetic resonance spectroscopy (³¹P-MRS) in unaffected siblings, compared to first episode psychosis (FEP) patients and healthy controls.

Methods

21 unaffected siblings, 32 FEP patients (including schizophrenia spectrum and affective psychoses), and 21 controls underwent ³¹P-MRS in the frontal lobe (6×6×4cm³) on a 4T MR scanner, using custom-designed dual-tuned surface coil with outer volume suppression. Brain parenchymal pH and st

SUBMITTER: Chouinard VA 

PROVIDER: S-EPMC5581291 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature