The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4⁺ T Cells.

ABSTRACT: Short-chain fatty acids (SCFAs), which are generated by the bacterial fermentation of dietary fibers, promote expansion of regulatory T cells (Tregs). Potential therapeutic value of SCFAs has been recently highlighted in the experimental models of T cell-mediated autoimmunity and allergic inflammation. These studies suggest that physiological intestinal concentrations of SCFAs within the millimolar range are crucial for dampening inflammation-mediated processes. Here, we describe opposing effects of SCFAs on T cell-mediated immune responses. In accordance with published data, lower butyrate concentrations facilitated differentiation of Tregs in vitro and in vivo under steady-state conditions. In contrast, higher concentrations of butyrate induced expression of the transcripti

SUBMITTER: Kespohl M 

PROVIDER: S-EPMC5581317 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature