Insm1a Regulates Motor Neuron Development in Zebrafish.

ABSTRACT: Insulinoma-associated1a (insm1a) is a zinc-finger transcription factor playing a series of functions in cell formation and differentiation of vertebrate central and peripheral nervous systems and neuroendocrine system. However, its roles on the development of motor neuron have still remained uncovered. Here, we provided evidences that insm1a was a vital regulator of motor neuron development, and provided a mechanistic understanding of how it contributes to this process. Firstly, we showed the localization of insm1a in spinal cord, and primary motor neurons (PMNs) of zebrafish embryos by in situ hybridization, and imaging analysis of transgenic reporter line Tg(insm1a: mCherry)^ntu805 . Then we demonstrated that the deficiency of insm1a in

SUBMITTER: Gong J 

PROVIDER: S-EPMC5581358 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature