Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome.

ABSTRACT:

Background

Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical implications in acute respiratory distress syndrome (ARDS) patients and to explore histone-mediated effects through ex-vivo investigations.

Methods

Extracellular histones, cytokine profiles and clinical data from 96 ARDS patients and 30 healthy volunteers were obtained. Human bronchial epithelial cells (BEAS-2B), human pulmonary artery endothelial cells (HPAEC), and human monocytic U937 cells were exposed to bronchoalveolar lavage fluid (BALF) collected from ARDS patients, and cellular damage and cytokine production were assessed. Furthermore, the effect of hi

SUBMITTER: Lv X 

PROVIDER: S-EPMC5581408 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature