Pneumococcal 23B Molecular Subtype Identified Using Whole Genome Sequencing.

ABSTRACT: The polysaccharide capsule is a major virulence factor of Streptococcus pneumoniae and the target of all currently licensed pneumococcal vaccines. At present, there are 92 serologically distinct pneumococcal serotypes. Structural and antigenic variation of capsular types is the result of genetic variation within the capsular polysaccharide synthesis (CPS) locus; however, genetic variation may not always result in phenotypic differences which produce novel serotypes. With the introduction of high throughput whole genome sequencing, discovery of novel genotypic variants is not unexpected and this study describes a novel variant of the serotype 23B CPS operon. This novel variant was characterized as a novel genotypic subtype (23B1) with ∼70% homology to the published 23B CPS sequence. High se

SUBMITTER: Kapatai G 

PROVIDER: S-EPMC5581491 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature