High expression of CPNE3 predicts adverse prognosis in acute myeloid leukemia.

ABSTRACT: CPNE3, a member of a Ca²⁺ -dependent phospholipid-binding protein family, was identified as a ligand of ERBB2 and has a more general role in carcinogenesis. Here, we identified the prognostic significance of CPNE3 expression in acute myeloid leukemia (AML) patients based on two datasets. In the first microarray dataset (n = 272), compared to low CPNE3 expression (CPNE3^low ), high CPNE3 expression (CPNE3^high ) was associated with adverse overall survival (OS, P < 0.001) and event-free survival (EFS, P < 0.001). In the second independent group of AML patients (TCGA dataset, n = 179), CPNE3^high was also associated with adverse OS and EFS (OS, P = 0.01; EFS, P = 0.036). Notably, among CPNE3^high patients, those received allogenic hematopoie

SUBMITTER: Fu L 

PROVIDER: S-EPMC5581509 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature