Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.

ABSTRACT: Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti-tumor immunity. Recently, we reported a novel CD8⁺ memory T cell population with a chemo-resistance property, "young memory" T (T_YM ) cells. In this study, we investigated the proportion and function of T_YM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of T_YM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti-EBV CTLs were induced using mixed lymphocyte peptide culture, from not only T_YM cells but also T_CM and T_EM cells. No CTLs directed to tumor-associated antigens were induced. I

SUBMITTER: Shibayama Y 

PROVIDER: S-EPMC5581517 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature