Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system.

ABSTRACT:

Background

A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA) or heterozygosity at the MHC are more important.

Methods

To do this we used captive house sparrows (Passer domesticus) to survey MHC diversity and immune function controlling for several environmental factors. MHC class I alleles

SUBMITTER: Lukasch B 

PROVIDER: S-EPMC5581531 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature