Atropos: specific, sensitive, and speedy trimming of sequencing reads.

ABSTRACT: A key step in the transformation of raw sequencing reads into biological insights is the trimming of adapter sequences and low-quality bases. Read trimming has been shown to increase the quality and reliability while decreasing the computational requirements of downstream analyses. Many read trimming software tools are available; however, no tool simultaneously provides the accuracy, computational efficiency, and feature set required to handle the types and volumes of data generated in modern sequencing-based experiments. Here we introduce Atropos and show that it trims reads with high sensitivity and specificity while maintaining leading-edge speed. Compared to other state-of-the-art read trimming tools, Atropos achieves significant increases in trimming accuracy while remaining competiti

SUBMITTER: Didion JP 

PROVIDER: S-EPMC5581536 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature