Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer.

ABSTRACT: Noninvasive biomarkers that detect the activity of important oncogenic drivers could significantly improve cancer diagnosis and management of treatment. The goal of this study was to determine whether ⁶⁸Ga-citrate (which avidly binds to circulating transferrin) can detect MYC-positive prostate cancer tumors, as the transferrin receptor is a direct MYC target gene. PET imaging paired with ⁶⁸Ga-citrate and molecular analysis of preclinical models, human cell-free DNA (cfDNA), and clinical biopsies were conducted to determine whether ⁶⁸Ga-citrate can detect MYC-positive prostate cancer. Importantly, ⁶⁸Ga-citrate detected human prostate cancer models in a MYC-dependent fashion. In patients with castration-resistant prostate cancer, analysis of cfDNA

SUBMITTER: Aggarwal R 

PROVIDER: S-EPMC5581675 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature