Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms.

ABSTRACT: Purpose: Adrenal incidentalomas must be differentiated from adrenocortical cancer (ACC). Currently, size, growth, and imaging characteristics determine the potential for malignancy but are imperfect. The aim was to evaluate whether urinary small molecules (<800 Da) are associated with ACC.Experimental Design: Preoperative fasting urine specimens from patients with ACC (n = 19) and benign adrenal tumors (n = 46) were analyzed by unbiased ultraperformance liquid chromatography/mass spectrometry. Creatinine-normalized features were analyzed by Progenesis, SIMCA, and unpaired t test adjusted by FDR. Features with an AUC >0.8 were identified through fragmentation patterns and database searches. All lead features were assessed in an independent set from patient

SUBMITTER: Patel D 

PROVIDER: S-EPMC5581680 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature