Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase.

ABSTRACT: Tissue infiltration and elevated peripheral circulation of granulocytic myeloid-derived cells is associated with poor outcomes in prostate cancer and other malignancies. Although myeloid-derived cells have the ability to suppress T-cell function, little is known about the direct impact of these innate cells on prostate tumor growth. Here, it is reported that granulocytic myeloid-derived suppressor cells (MDSC) are the predominant tumor-infiltrating cells in prostate cancer xenografts established in athymic nude mice. MDSCs significantly increased in number in the peripheral circulation as a function of xenograft growth and were successfully depleted in vivo by Gr-1 antibody treatment. Importantly, MDSC depletion significantly decreased xenograft growth. We hypothesized that granuloc

SUBMITTER: Lerman I 

PROVIDER: S-EPMC5581693 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature