Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia.

ABSTRACT: Treatment-resistant schizophrenia (TRS) affects around one-third of individuals with schizophrenia. Although a number of sociodemographic and clinical predictors of TRS have been identified, data on the genetic risk of TRS are sparse. We aimed to investigate the association between a polygenic risk score for schizophrenia and treatment resistance in patients with schizophrenia. We conducted a nationwide, population-based follow-up study among all Danish individuals born after 1981 and with an incident diagnosis of schizophrenia between 1999 and 2007. Based on genome-wide data polygenic risk scores for schizophrenia were calculated in 862 individuals with schizophrenia. TRS was defined as either clozapine initiation or at least 2 periods of different antipsychotic monotherapies and still be

SUBMITTER: Wimberley T 

PROVIDER: S-EPMC5581885 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature