Proton beam reirradiation for locally recurrent pancreatic adenocarcinoma.

ABSTRACT:

Background

Local recurrence following definitive treatment for pancreatic adenocarcinoma is common and can be associated with significant morbidity and mortality. Retreatment options for these patients are limited. Proton beam reirradiation (PRT) may limit dose and toxicity to previously irradiated normal tissues in patients without evidence of metastatic disease.

Methods

Between 8/2010-2/2015, 15 patients with isolated, locally-recurrent pancreatic cancer were treated with PRT. Acute toxicity was graded using CTC v 4.0 and defined as occurring within 90 days. Kaplan-Meier survival analysis was performed from the start of PRT. A log-rank test was used to compare survival with or without concurrent chemotherapy.

Results

Median follow-up was 15.7 months [2-48] from the

SUBMITTER: Boimel PJ 

PROVIDER: S-EPMC5582048 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature