Finite cell-size effects on protein variability in Turing patterned tissues.

ABSTRACT: Herein we present a framework to characterize different sources of protein expression variability in Turing patterned tissues. In this context, we introduce the concept of granular noise to account for the unavoidable fluctuations due to finite cell-size effects and show that the nearest-neighbours autocorrelation function provides the means to measure it. To test our findings, we perform in silico experiments of growing tissues driven by a generic activator-inhibitor dynamics. Our results show that the relative importance of different sources of noise depends on the ratio between the characteristic size of cells and that of the pattern domains and on the ratio between the pattern amplitude and the effective intensity of the biochemical fluctuations. Importantly, our framework provi

SUBMITTER: Buceta J 

PROVIDER: S-EPMC5582127 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature