The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains.

ABSTRACT: Schizophrenia (SCZ) is a serious neuropsychiatric disorder that manifests through several symptoms from early adulthood. Numerous studies over the last decades have led to significant advances in increasing our understanding of the factors involved in SCZ. For example, mass spectrometry-based proteomic analysis has provided important insights by uncovering protein dysfunctions inherent to SCZ. Here, we present a comprehensive analysis of the nuclear proteome of postmortem brain tissues from corpus callosum (CC) and anterior temporal lobe (ATL). We show an overview of the role of deregulated nuclear proteins in these two main regions of the brain: the first, mostly composed of glial cells and axons of neurons, and the second, represented mainly by neuronal cell bodies. These samples were co

SUBMITTER: Saia-Cereda VM 

PROVIDER: S-EPMC5582429 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature