Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort.

ABSTRACT: Suicidal behavior is a complex and devastating phenotype with a heritable component that has not been fully explained by existing common genetic variant analyses. This study represents the first large-scale DNA sequencing project designed to assess the role of rare functional genetic variation in suicidal behavior risk. To accomplish this, whole-exome sequencing data for ∼19,000 genes were generated for 387 bipolar disorder subjects with a history of suicide attempt and 631 bipolar disorder subjects with no prior suicide attempts. Rare functional variants were assessed in all exome genes as well as pathways hypothesized to contribute to suicidal behavior risk. No result survived conservative Bonferroni correction, though many suggestive findings have arisen that merit additional attention.

SUBMITTER: Monson ET 

PROVIDER: S-EPMC5582499 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature