HMGA2 regulates lung cancer proliferation and metastasis.

ABSTRACT:

Background

This study aimed to explore the effects of HMGA2 on cell proliferation and metastases in lung cancer and its underlying mechanism.

Methods

HMGA2 expression in lung cancer tissues and its association with overall survival were analyzed based on data from a public database. The roles of HMGA2 were validated via loss-of-function and gain-of-function experiments in vitro. HMGA2 regulation by microRNA-195 (miR-195) was validated by real time-PCR, Western blotting, and luciferase reporter assays.

Results

HMGA2 was upregulated and associated with reduced overall survival in patients with lung adenocarcinoma. HMGA2 knockdown suppressed the proliferation and motility of H1299 cells, while HMGA2 ectopic expression in A549 cells increased cell proliferation and migrat

SUBMITTER: Gao X 

PROVIDER: S-EPMC5582513 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature