Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.

ABSTRACT: Most Foxp3⁺ regulatory T (T_reg) cells develop in the thymus as a functionally mature T cell subpopulation specialized for immune suppression. Their cell fate appears to be determined before Foxp3 expression; yet molecular events that prime Foxp3^- T_reg precursor cells are largely obscure. We found that T_reg cell-specific super-enhancers (T_reg-SEs), which were associated with Foxp3 and other T_reg cell signature genes, began to be activated in T_reg precursor cells. T cell-specific deficiency of the genome organizer Satb1 impaired T_reg-SE activation and the subsequent expression of T_reg signature genes, causing severe autoimmunity due to T_reg cell deficiency. These results s

SUBMITTER: Kitagawa Y 

PROVIDER: S-EPMC5582804 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature