Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study.

ABSTRACT:

Objective

To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, and risk of dementia later in life.

Design

Analysis of prospective data from a multiethnic population based cohort.

Setting

Kaiser Permanente Northern California Medical Group, a healthcare delivery organisation.

Participants

10,276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 and who were still members of the health plan in 1994.

Main outcome measures

Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipi

SUBMITTER: Whitmer RA 

PROVIDER: S-EPMC558283 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature