IL-4 up-regulates cyclooxygenase-1 expression in macrophages.

ABSTRACT: Macrophages use various cell-surface receptors to sense their environment and undergo polarized responses. The cytokines, interleukin (IL)-4 and IL-13, released from T-helper type 2 (Th2) cells, drive macrophage polarization toward an alternatively activated phenotype (M2). This phenotype is associated with the expression of potent pro-resolving mediators, such as the prostaglandin (PG) D₂-derived cyclopentenone metabolite, 15d-PGJ₂, produced by the cyclooxygenase (Ptgs; Cox) pathway. Interestingly, IL-4 treatment of bone marrow-derived macrophages (BMDMs) significantly down-regulates Cox-2 protein expression, whereas Cox-1 levels are significantly increased. This phenomenon not only challenges the dogma that Cox-1 is only developmentally regulated, but also de

SUBMITTER: Shay AE 

PROVIDER: S-EPMC5582846 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature