Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function.

ABSTRACT: Innate immune cells of the respiratory tract are the first line of defense against pathogenic and environmental insults. Failure of these cells to perform their immune functions leaves the host susceptible to infection and may contribute to impaired resolution of inflammation. While combustible tobacco cigarettes have been shown to suppress respiratory immune cell function, the effects of flavored electronic cigarette liquids (e-liquids) and individual flavoring agents on respiratory immune cell responses are unknown. We investigated the effects of seven flavored nicotine-free e-liquids on primary human alveolar macrophages, neutrophils, and natural killer (NK) cells. Cells were challenged with a range of e-liquid dilutions and assayed for their functional responses to pathogenic stimuli.

SUBMITTER: Clapp PW 

PROVIDER: S-EPMC5582929 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature