Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats.

ABSTRACT: The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats were analyzed with Agilent's whole rat genome microarray. The RVLM gene expression profile varied with age, and an association between chronologica

SUBMITTER: Balivada S 

PROVIDER: S-EPMC5582943 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature