An Unconventional Mechanistic Insight into SCF₃ Formation from Difluorocarbene: Preparation of ¹⁸ F-Labeled α-SCF₃ Carbonyl Compounds.

ABSTRACT: Trifluoromethylthiolation by sulfuration of difluorocarbene with elemental sulfur is described for the first time, which overrides long-standing trifluoromethyl anion-based theory. Mechanistic elucidation reveals an unprecedented chemical process for the formation of thiocarbonyl fluoride and also enables transition-metal-mediated trifluoromethylthiolation and [¹⁸ F]trifluoromethylthiolation of α-bromo carbonyl compounds with broad substrate scope and compatibility.

SUBMITTER: Zheng J 

PROVIDER: S-EPMC5582945 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature