The influence of high intensity exercise and the Val66Met polymorphism on circulating BDNF and locomotor learning.

ABSTRACT: Brain-derived neurotrophic factor (BDNF) has been directly related to exercise-enhanced motor performance in the neurologically injured animal model; however literature concerning the role of BDNF in the enhancement of motor learning in the human population is limited. Previous studies in healthy subjects have examined the relationship between intensity of an acute bout of exercise, increases in peripheral BDNF and motor learning of a simple isometric upper extremity task. The current study examined the role of high intensity exercise on upregulation of peripheral BDNF levels as well as the role of high intensity exercise in mediation of motor learning and retention of a novel locomotor task in neurologically intact adults. In addition, the impact of a single nucleotide polymorphism in the

SUBMITTER: Helm EE 

PROVIDER: S-EPMC5583008 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature