Genome-wide association study of language performance in Alzheimer's disease.

ABSTRACT: Language impairment is common in prodromal stages of Alzheimer's disease (AD) and progresses over time. However, the genetic architecture underlying language performance is poorly understood. To identify novel genetic variants associated with language performance, we analyzed brain MRI and performed a genome-wide association study (GWAS) using a composite measure of language performance from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n=1560). The language composite score was associated with brain atrophy on MRI in language and semantic areas. GWAS identified GLI3 (GLI family zinc finger 3) as significantly associated with language performance (p<5×10^-8). Enrichment of GWAS association was identified in pathways related to nervous system development and glutamate rece

SUBMITTER: Deters KD 

PROVIDER: S-EPMC5583024 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature