Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle.

ABSTRACT:

Background

Molecular signaling events associated with the necroinflammatory changes in nonalcoholic steatohepatitis (NASH) are not well understood.

Aims

To understand the molecular basis of NASH, we evaluated reversible phosphorylation events in hepatic tissue derived from Class III obese subjects by phosphoproteomic means with the aim of highlighting key regulatory pathways that distinguish NASH from non-alcoholic fatty liver disease (also known as simple steatosis; SS).

Materials & methods

Class III obese subjects undergoing bariatric surgery underwent liver biopsy (eight normal patients, eight with simple steatosis, and eight NASH patients). Our strategy was unbiased, comparing global differences in liver protein reversible phosphorylation events across the 24 subj

SUBMITTER: Wattacheril J 

PROVIDER: S-EPMC5583035 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature