Regulation of Endoplasmic Reticulum-Mitochondria Ca²⁺ Transfer and Its Importance for Anti-Cancer Therapies.

ABSTRACT: Inter-organelle membrane contact sites are emerging as major sites for the regulation of intracellular Ca²⁺ concentration and distribution. Here, extracellular stimuli operate on a wide array of channels, pumps, and ion exchangers to redistribute intracellular Ca²⁺ among several compartments. The resulting highly defined spatial and temporal patterns of Ca²⁺ movement can be used to elicit specific cellular responses, including cell proliferation, migration, or death. Plasma membrane (PM) also can directly contact mitochondria and endoplasmic reticulum (ER) through caveolae, small invaginations of the PM that ensure inter-organelle contacts, and can contribute to the regulation of numerous cellular functions through scaffolding proteins such as caveolins. PM

SUBMITTER: Pedriali G 

PROVIDER: S-EPMC5583168 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature