Differences in telomere length between homologous chromosomes in humans.

ABSTRACT: Telomeres are important structures for DNA replication and chromosome stability during cell growth. Telomere length has been correlated with the division potential of human cells and has been found to decrease with age in healthy individuals. Nevertheless, telomere lengths within the same cell are heterogeneous and certain chromosome arms typically have either short or long telomeres. Both the origin and the physiological consequences of this heterogeneity in telomere length remain unknown. In this study we used quantitative telomeric FISH combined with a method to identify the parental origin of chromosomes to show that significant differences in relative telomere intensities are frequently observed between chromosomal homologs in short-term stimulated cultures of peripheral blood lymphoc

SUBMITTER: Londono-Vallejo JA 

PROVIDER: S-EPMC55832 | biostudies-literature | 2001 Aug

REPOSITORIES: biostudies-literature