Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer.

ABSTRACT: While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma. Whereas benign epithelium in prostates with and without tumor were similar in gene expression space, stroma away from tumor was significantly different from that in prostates without cancer. A stromal gene signature reflecting bone remodeling and immune-r

SUBMITTER: Tyekucheva S 

PROVIDER: S-EPMC5583238 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature