Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine.

ABSTRACT: Chronic constipation is a prevalent functional gastrointestinal disorder accompanied with intestinal dysbiosis. However, causal relationship between dysbiosis and constipation remains poorly understood. Serotonin transporter (SERT) is a transmembrane transport protein which re-uptakes excessive 5-hydroxytryptamine (5-HT) from effective location to terminate its physiological effects and involves in regulating gastrointestinal motility. In this study, fecal microbiota from patients with constipation and healthy controls were transplanted into the antibiotic depletion mice model. The mice which received fecal microbiota from patients with constipation presented a reducing in intestinal peristalsis and abnormal defecation parameters including the frequency of pellet expulsion, fecal weight an

SUBMITTER: Cao H 

PROVIDER: S-EPMC5583244 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature