Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.

ABSTRACT: Cell division cycle 42 (CDC42) plays important roles in polarity establishment and maintenance as well as cell cycle progression and cell division. Although disruption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumorigenesis are still poorly understood. Here we find that Cdc42 deficiency inhibits the Kras ^G12D -induced lung alveoli tumor formation, while conversely promotes bronchiole tumor formation in mice. Bronchial Cdc42 loss destroys contact inhibition potentially through cell polarity disruption, and results in increased tumor formation. In contrast, deletion of Cdc42 in alveoli cells prevents Kras ^G12D -induced cell proliferation, which leads to reduced tumor formation. Further analyses of clinical specimens uncover

SUBMITTER: Zheng C 

PROVIDER: S-EPMC5583260 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature