Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface.

ABSTRACT:

Aims/hypothesis

Obesity triggers complex inflammatory networks within the innate immune system. During pregnancy, the placenta amplifies the low-grade inflammation through activation of Toll-like receptor 4 (TLR4) signalling pathways. The purpose of this study was to investigate the impact of obesity on placental TLR4 expression and inflammatory signals. The secondary aim was to analyse the placental cell type responsible for TLR4 activation.

Methods

Thirty-nine women recruited at term-scheduled Caesarean section were grouped according to their pre-gravid BMI (<25 kg/m(2) and >30 kg/m(2)). Placenta, venous maternal and cord blood were obtained at delivery for analysis. Data were analysed with linear regression and Spearman's rank correlation coefficient analysis.

Results<

SUBMITTER: Yang X 

PROVIDER: S-EPMC5583648 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature