Red blood cells release microparticles containing human argonaute 2 and miRNAs to target genes of Plasmodium falciparum.

ABSTRACT: Red blood cells (RBCs) are known to function as a refuge for providing food resources and as a shelter against the host's immune system after malaria parasite (Plasmodium) infection. Recent studies have reported significant production of extracellular vesicles (microparticles, MPs) in the circulation of malaria patients. However, it is unclear how these extracellular vesicles are generated and what their biological functions are. In this study, we isolated the MPs from a culture medium of normal RBCs and malaria parasite-infected RBCs (iRBCs), compared their quantity and origins, and profiled their miRNAs by deep sequencing. We found a much larger number of MPs released in the culture of iRBCs than in the culture of normal RBCs. Further investigation indicated that, in these MPs, human arg

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5583671 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature