Effect of maternal vitamin D₃ supplementation on maternal health, birth outcomes, and infant growth among HIV-infected Tanzanian pregnant women: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Vitamin D has significant immunomodulatory effects on both adaptive and innate immune responses. Observational studies indicate that adults infected with HIV with low vitamin D status may be at increased risk of mortality, pulmonary tuberculosis, and HIV disease progression. Growing observational evidence also suggests that low vitamin D status in pregnancy may increase the risk of adverse birth and infant health outcomes. As a result, antiretroviral therapy (ART) adjunct vitamin D₃ supplementation may improve the health of HIV-infected pregnant women and their children.

Methods/design

The Trial of Vitamins-5 (ToV5) is an individually randomized, double-blind, placebo-controlled trial of maternal vitamin D₃ (cholecalciferol) supplementation c

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC5584035 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature