The miR-106a~363^Xpcl1 miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27^Kip1 cell cycle inhibitor.

ABSTRACT: The miR-106a~363 cluster encodes 6 miRNAs on the X-chromosome which are abundant in blood cells and overexpressed in a variety of malignancies. The constituent miRNA of miR-106a~363 have functional activities in vitro that are predicted to be both oncogenic and tumor suppressive, yet little is known about their physiological functions in vivo. Mature miR-106a~363 (Mirc2) miRNAs are processed from an intragenic, non-protein encoding gene referred to as Xpcl1 (or Kis2), situated at an X-chromosomal locus frequently targeted by retroviruses in murine lymphomas. The oncogenic potential of miR-106a~363 ^Xpcl1 has not been proven, nor its potential role in T cell development. We show that miR106a~363 levels normally drop at the CD4+/CD8+ double positi

SUBMITTER: Kuppers DA 

PROVIDER: S-EPMC5584189 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature