Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis.

ABSTRACT: Angiogenesis promotes tumor development. Understanding the crucial factors regulating tumor angiogenesis may reveal new therapeutic targets. Human GT198 (PSMC3IP or Hop2) is an oncoprotein encoded by a DNA repair gene that is overexpressed in tumor stromal vasculature to stimulate the expression of angiogenic factors. Here we show that pericytes expressing GT198 give rise to tumor cells through angiogenesis. GT198⁺ pericytes and perivascular cells are commonly present in the stromal compartment of various human solid tumors and rodent xenograft tumor models. In human oral cancer, GT198⁺ pericytes proliferate into GT198⁺ tumor cells, which migrate into lymph nodes. Increased GT198 expression is associated with increased lymph node metastasis and decre

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5584272 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature