Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.

ABSTRACT: The development of effective treatments against cancers is urgently needed, and the accumulation of CD8⁺ T cells within tumors is especially important for cancer prognosis. Although their mechanisms are still largely unknown, growing evidence has indicated that innate immune cells have important effects on cancer progression through the production of various cytokines. Here, we found that basic leucine zipper transcription factor ATF-like 2 (Batf2) has an antitumor effect. An s.c. inoculated tumor model produced fewer IL-12 p40⁺ macrophages and activated CD8⁺ T cells within the tumors of Batf2^-/- mice compared with WT mice. In vitro studies also revealed that the IL-12 p40 expression was significantly lower in Batf2

SUBMITTER: Kanemaru H 

PROVIDER: S-EPMC5584452 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature