Gestational diabetes and offspring birth size at elevated environmental pollutant exposures.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is associated with increased availability of glucose and macronutrients in fetal circulation and macrosomia. Therefore, the role of GDM in the association between metabolism-disrupting chemicals and birth size deserves attention.

Objective

We examined whether GDM may mediate or modify the associations between maternal environmental pollutant exposures and offspring birth size measures.

Methods

We analyzed 604 Faroese pregnant women and their offsprings born in 1997-2000. Maternal pregnancy serum concentrations of organochlorine compounds (OCs: polychlorinated biphenyl (PCB) congeners and dichlorodiphenyldichloroethylene (DDE)), and five perfluoroalkyl substances (PFASs), and hair and cord blood mercury concentrations were

SUBMITTER: Valvi D 

PROVIDER: S-EPMC5584560 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature