Human genetic insights into lipoproteins and risk of cardiometabolic disease.

ABSTRACT:

Purpose of review

Human genetic studies have been successfully used to identify genes and pathways relevant to human biology. Using genetic instruments composed of loci associated with human lipid traits, recent studies have begun to clarify the causal role of major lipid fractions in risk of cardiometabolic disease.

Recent findings

The causal relationship between LDL cholesterol and coronary disease has been firmly established. Of the remaining two major fractions, recent studies have found that HDL cholesterol is not likely to be a causal particle in atherogenesis, and have instead shifted the causal focus to triglyceride-rich lipoproteins. Subsequent results are refining this view to suggest that triglycerides themselves might not be causal, but instead may be a surrogate

SUBMITTER: Stitziel NO 

PROVIDER: S-EPMC5584563 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature