Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways.

ABSTRACT: Identifying essential genes in a given organism is important for research on their fundamental roles in organism survival. Furthermore, if possible, uncovering the links between core functions or pathways with these essential genes will further help us obtain deep insight into the key roles of these genes. In this study, we investigated the essential and non-essential genes reported in a previous study and extracted gene ontology (GO) terms and biological pathways that are important for the determination of essential genes. Through the enrichment theory of GO and KEGG pathways, we encoded each essential/non-essential gene into a vector in which each component represented the relationship between the gene and one GO term or KEGG pathway. To analyze these relationships, the maximum relevance

SUBMITTER: Chen L 

PROVIDER: S-EPMC5584762 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature