Variation in Hsp70-1A Expression Contributes to Skin Color Diversity.

ABSTRACT: The wide range in human skin color results from varying levels of the pigment melanin. Genetic mechanisms underlying coloration differences have been explored, but identified genes do not account for all variation seen in the skin color spectrum. Post-transcriptional and post-translational regulation of factors that determine skin color, including melanin synthesis in epidermal melanocytes, melanosome transfer to keratinocytes, and melanosome degradation, is also critical for pigmentation. We therefore investigated proteins that are differentially expressed in melanocytes derived from either white or African American skin. Two-dimensional gel electrophoresis and mass spectrometry demonstrated that heat shock protein 70-1A (Hsp70-1A) protein levels were significantly higher in African Ameri

SUBMITTER: Murase D 

PROVIDER: S-EPMC5584801 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature