Effective heating of magnetic nanoparticle aggregates for in vivo nano-theranostic hyperthermia.

ABSTRACT: Magnetic resonance (MR) nano-theranostic hyperthermia uses magnetic nanoparticles to target and accumulate at the lesions and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. Preclinical and translational applications of MR nano-theranostic hyperthermia are currently limited by a few major theoretical difficulties and experimental challenges in in vivo conditions. For example, conventional models for estimating the heat generated and the optimal magnetic nanoparticle sizes for hyperthermia do not accurately reproduce reported in vivo experimental results. In this work, a revised cluster-based model was proposed to predict the specific loss power (SLP) by explicitly considering magnetic nanoparticle agg

SUBMITTER: Wang C 

PROVIDER: S-EPMC5584909 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature