Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort.

ABSTRACT:

Background

Fluoroquinolone is a commonly prescribed antimicrobial agent, and up to 20% of its users registers adverse gastroenterological symptoms. We aimed to evaluate the association between use of fluoroquinolone and gastrointestinal tract perforation.

Methods

We conducted a nested case-control study on a national health insurance claims database between 1998 and 2011. The use of fluoroquinolones was classified into current (< 60 days), past (61-365 days prior to the index date) and any prior year use of fluoroquinolones. We used the conditional logistic regression model to estimate rate ratios (RRs), adjusting or matching by a disease risk score (DRS).

Results

We identified a cohort of 17,510 individuals diagnosed with gastrointestinal perforation and matched them

SUBMITTER: Hsu SC 

PROVIDER: S-EPMC5584983 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature