Cognitive decline associated with pathological burden in primary age-related tauopathy.

ABSTRACT:

Introduction

Primary age-related tauopathy (PART) is a neuropathological diagnosis characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. Although most individuals over 50 years of age have evidence of NFTs, the clinical and cognitive consequences of PART are not known.

Methods

We evaluated 226 neuropathologically confirmed PART cases from the National Alzheimer's Coordinating Center database who participated in a total of 846 longitudinal neuropsychological assessments from the Alzheimer's Disease Center program's Uniform Data Set. Mixed-effects statistical models tested whether cognitive decline was associated with Braak stage NFT burden.

Results

Higher stages of NFT burden in PART, with no evidence or minimal evidence of amy

SUBMITTER: Jefferson-George KS 

PROVIDER: S-EPMC5585025 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature