Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.

ABSTRACT:

Background

Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel approach to the treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathways mediated via anandamide (N-arachidonylethanolamine [AEA]) and 2-arachidonoylglycerol (2-AG) in the regulation of anxiety are not well understood.

Methods

We utilized pharmacological augmentation and depletion combined with behavioral and electrophysiological approaches to probe the role of 2-AG signaling in the modulation of stress-induced anxiety and the functional redundancy between AEA and 2-AG signaling in the

SUBMITTER: Bedse G 

PROVIDER: S-EPMC5585044 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature