IL-17 Promotes Differentiation of Splenic LSK^- Lymphoid Progenitors into B Cells following Plasmodium yoelii Infection.

ABSTRACT: Lineage^-Sca-1⁺c-Kit^- (LSK^-) cells are a lymphoid progenitor population that expands in the spleen and preferentially differentiates into mature B cells in response to Plasmodium yoelii infection in mice. Furthermore, LSK^- derived B cells can subsequently contribute to the ongoing immune response through the generation of parasite-specific Ab-secreting cells, as well as germinal center and memory B cells. However, the factors that promote their differentiation into B cells in the spleen postinfection are not defined. In this article, we show that LSK^- cells produce the cytokine IL-17 in response to Plasmodium infection. Using Il-17ra^-/- mice, IL-17R signaling in cells other than LSK^-

SUBMITTER: Ghosh D 

PROVIDER: S-EPMC5585076 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature