Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth.

ABSTRACT: Bone strength is influenced by mineral density and macro- and microstructure. Research into factors that contribute to bone morphology and strength has focused on genetic, environmental and morphological factors (e.g., body mass index), but little is known regarding the impact of rates of skeletal elongation on adult skeletal morphology and strength. Using micro-CT, we examined the impact of rates of skeletal elongation on bone cortical and trabecular morphology, and on rates of estrogen-dependent bone loss in the tibia in CD-1 mice, and in mice with accelerated skeletal growth (Longshanks). Groups of adult mice (n = 7/group) were subjected to ovariectomy or sham surgeries, scanned for 6 weeks, and indices of bone morphology were collected. Results show that Longshanks mice had significant

SUBMITTER: Farooq S 

PROVIDER: S-EPMC5585176 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature