Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.

ABSTRACT: Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white matter damage. Using a mouse model where encephalopathy of prematurity is induced by systemic interleukin-1β administration, we undertake gene network analysis of the microglial transcriptomic response to injury, extend this by analysis of protein-protein interactions, transcription factors and human brain gene expression, and translate findings to living infants using imaging genomics. We show that DLG4 (PSD95) protein is synthesised by microglia in immature mouse and human,

SUBMITTER: Krishnan ML 

PROVIDER: S-EPMC5585205 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature