Uncovering specific changes in network wiring underlying the primate cerebrotype.

ABSTRACT: Regular scaling of brain networks during evolution has been proposed to be the major process leading to enlarged brains. Alternative views, however, suggest that deviations from regular scaling were crucial to the evolution of the primate brain and the emergence of different cerebrotypes. Here, we examined the scaling within the major link between the cerebellum and the cerebral cortex by studying the deep cerebellar nuclei (DCN). We compared the major axonal and dendritic wiring in the DCN of rodents and monkeys in search of regular scaling. We were able to confirm regular scaling within the density of neurons, the general dendritic length per neuron and the Purkinje cell axon length. However, we also observed specific modification of the scaling rules within the primates' largest and phy

SUBMITTER: Hamodeh S 

PROVIDER: S-EPMC5585288 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature